1. Chemical structure and properties
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HPMC is produced from natural cellulose after alkali treatment and etherification reaction using methyl chloride and propylene oxide. The hydroxyl group in its molecular structure is replaced by methoxy (-OCH3) and hydroxypropoxy (-CH2CHOHCH3) .
Its main features include:
High solubility: soluble in cold and hot water to form a transparent viscous solution.
Chemical stability: High resistance to acids and bases, less affected by light, heat and oxidation.
Thermal gelability: When heated, the viscosity of the solution decreases and forms a gel, which returns to its original state after cooling.
Excellent water retention: can significantly improve the water retention performance of the material.
Biocompatibility: Harmless to human body, excellent environmental performance.
2. Application in construction
Key applications of HPMC in the construction industry include:
(1) Dry mortar
HPMC is one of the most important additives in dry mortar, which can significantly improve the processing performance and construction quality of mortar:
Improve the water retention of mortar to avoid cracking or strength reduction caused by rapid evaporation of water.
Enhance the workability of mortar, improve lubricity and bonding properties.
Control the setting time of mortar to facilitate construction.
(2) Ceramic tile adhesives and grouts
Among tile adhesives, HPMC provides excellent slip resistance and open time, ensuring accurate tile positioning during application. As a component of caulking compounds, it improves flow and workability while enhancing adhesion and crack resistance.
(3) Waterproof coating and putty powder
HPMC enhances the film-forming properties of waterproof coatings, improves the coating's adhesion, water retention and construction smoothness. In putty powders, it improves application properties and ensures a flat, smooth coating.
(4) Self-leveling materials
HPMC regulates the rheological properties of self-leveling floors to ensure that the slurry has good fluidity and water retention and avoids delamination and cracking.
3. Advantages and Challenges
Advantages
Improved construction quality: The use of HPMC significantly improves the performance of building materials, making the construction process smoother.
Reduce costs: Reduce construction waste and extend service life by improving material performance.
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Environmental protection: non-toxic, harmless, biodegradable, and in line with the environmental protection requirements of modern buildings.
challenge
Complex production technology: High-quality HPMC requires strict production process control.
Cost Factor: The cost of HPMC is relatively high compared to some cheaper alternatives, but its performance advantages make up for this disadvantage.
4. Future development trends
With the promotion of green buildings and environmentally friendly materials, the demand for HPMC in the construction field will continue to grow. In the future, its research directions may include:
Modification technology: Improve the durability and versatility of HPMC through chemical modification.
Efficient and environmentally friendly: Develop more environmentally friendly production processes to reduce energy consumption and pollution in production.
Intelligent functional materials: Combined with other functional chemicals, HPMC is given more intelligent properties, such as self-healing, temperature sensitivity, etc.
Encapsulation, used in both medications and dietary supplements, is one of the most common processes used by pharmaceutical and nutraceutical companies worldwide. Two of the most popular types of empty capsules used by both industries are gelatin and HPMC (hydroxypropyl methylcellulose), also known as “vegetarian capsules.”
Today the global demand for empty capsules is skyrocketing. According to the the gelatin-based capsule market and the vegetarian-based capsule market combined are expected to grow from approximately $2,956.6 million in to around $6,378.6 million by , reflecting a compound annual growth rate (CAGR) of 8.0%.
Beyond the impressive growth and value of empty capsules in the human health and wellness, it is important to understand the differences between these types. Let’s take a look at each of these capsule types…
What are Gelatin capsules?
Gelatin capsules are composed of gelatin manufactured from collagen derived from pork or bovine sources. Bovine hide is considered to be one of the best choices, as it enables the capsules to be Kosher and Halal certified, meeting the religious and dietary needs of a broader range of consumers.
Gelatin capsules are commonly used in the global market, known for:
- Being the most common type of capsule used in the pharmaceutical industry.
- Offering flexibility for a wide range of formulations and applications.
- Ability to include custom flavors to mask unpleasant smell and taste of the encapsulated drug.
- Recognized by most of the world's regulatory authorities as “Generally Recognized as Safe (GRAS)” for human consumption.
- Do not contain GMOs, are completely natural, and are allergen free.
- Cost-efficiency with production cost about 30% lower than other alternatives.
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What are Vegetarian HPMC Capsules and why are they popular?
HPMC Capsules or Vegetarian Capsules, made from plant-based hydroxypropyl methylcellulose, offer an alternative to animal-derived capsules. Hypromellose Capsules have gained popularity due to their natural origin and superior stability, particularly in markets demanding vegan or vegetarian options, being an effective alternative to gelatin-based capsules.
Their most notable characteristics are:
- Provide health-conscious consumers with a natural, 100% vegetable-derived alternative to animal-derived capsules.
- Ideal for individuals with religion-based dietary restrictions.
- Offer the ability to address today's API challenges as well as the requirement for rapid product development.
- Can withstand high temperature and humidity conditions, protecting their content from all kinds of fluctuations; this makes them ideal for hygroscopic formulations.
The key HPMC consumption markets are located in developed countries with a market share above 52%, with North America and Europe having the biggest percentage in the market.
Which is better: Gelatin or HPMC Capsules?
Choosing between gelatin or vegetable capsules depends on several factors, including the material to encapsulate, costs, and target audience. Both types of capsules come in various sizes, colors, and designs and can be customized to fit any demand.
Both gelatin and HPMC capsules are durable if certain conditions are met. The shelf life for gelatin capsules is five years if the capsules are kept at the recommended storage temperature of 59°-77°Fahrenheit / 15°-25°Celsius, with a relative humidity between 35 and 65%. HPMC capsules also have a five-year shelf life, although they can tolerate greater heat and humidity. Here the recommended conditions are more forgiving: storage temperature of 59°-86°Fahrenheit / 15°-30°Celsius with a relative humidity between 35 and 70%.
Over the years, gelatin capsules have been the preferred choice of hundreds of pharmaceutical and nutraceutical industries and are forecasted to remain relatively popular. However, as more consumers seek “natural” and vegan products, vegetable-based capsules have begun to penetrate leading markets in Western Europe, Canada and the United States.
From a chemical perspective:
- Gelatin capsules dissolve quickly in stomach acid, making them suitable for immediate-release formulations.
- HPMC capsules exhibit resistance to gastric acids and are ideal for delayed-release and enteric-coated applications.
Both capsule types offer customization in size, color, and branding, and maintain a shelf life of up to five years under recommended conditions:
- Gelatin: 15°-25°C (59°-77°F) and 35-65% RH.
- HPMC: 15°-30°C (59°-86°F) and 35-70% RH.
With growing demand for plant-based and sustainable health products, Plant-based capsules are expanding rapidly in leading markets. However, gelatin-based capsules continue to be the standard in many pharmaceutical formulations due to their cost advantage and regulatory familiarity.
Both G-CAPS® gelatin capsules and K-CAPS® HPMC capsules, offer effective solutions depending on specific application and consumer expectations
Frecuentky Asked Questions (FAQ)
What are the benefits of hypromellose vegan capsules?
Hypromellose vegan capsules provide a plant-based solution free from allergens, preservatives, and GMOs. Their resistance to environmental conditions (heat and humidity) ensures better protection for sensitive ingredients, particularly useful for hygroscopic and delayed-release formulations.
Are HPMC capsules as effective as gelatin capsules?
Yes, HPMC capsules are equally effective and often better for moisture-sensitive or plant-based products. With Kosher, Halal, and vegan certifications, they are a versatile choice for today’s health-conscious B2B markets in pharma and nutra sectors.
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